Effects of Sugammadex Plus Rocuronium vs Neostigmine Plus Cisatracurium During Renal Transplantation on Graft Function: A Retrospective, Case-Control Study

Rocuronium can be used in patients with severe renal failure (creatinine clearance <30 mL/min), but the duration of muscle relaxation is longer and results an increased risk postoperative residual neuromuscular block. antagonized by sugammadex, elimination complex they make (rocuronium-sugammadex complex) varies according to function. Two case reports/series have reported use rocuronium-sugammadex during transplantation. A recently published retrospective study showed no differences creatinine levels receiving kidney This case-control aims investigate effects rocuronium-sugammadex, transplantation, on transplanted We analyzed 113 medical records undergoing transplantation from January 2015 December 2018. Forty-seven were excluded because did not report administration one following drugs transplantation: rocuronium, cisatracurium, neostigmine. The demographics donors collected along data: blood urea creatinine, serum urinary electrolytes, diuresis. Marginal, single, or double transplantations; Karpinski scores; histologic evaluations collected. included data 66 reports Blood at 6, 12, 24 hours significantly lower rocuronium + sugammadex group than cisatracurium neostigmine 6 P = .05, 12 .038, .049). for after (urea 0 .025, .011, .03, .011). found statistically significant sodium, potassium, calcium, diuresis, potassium before In this study, transplant surgery affect relevant recovery outcomes first week